Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs).
Identifieur interne : 000020 ( Main/Exploration ); précédent : 000019; suivant : 000021Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs).
Auteurs : Tiffany J. Rios-Fuller [États-Unis] ; Melanie Mahe [États-Unis] ; Beth Walters [États-Unis] ; Dounia Abbadi [États-Unis] ; Sandra Pérez-Baos [États-Unis] ; Abhilash Gadi [États-Unis] ; John J. Andrews [États-Unis] ; Olga Katsara [États-Unis] ; C Theresa Vincent [États-Unis, Suède] ; Robert J. Schneider [États-Unis]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2020.
Abstract
Non-communicable diseases (NCDs) are medical conditions that, by definition, are non-infectious and non-transmissible among people. Much of current NCDs are generally due to genetic, behavioral, and metabolic risk factors that often include excessive alcohol consumption, smoking, obesity, and untreated elevated blood pressure, and share many common signal transduction pathways. Alterations in cell and physiological signaling and transcriptional control pathways have been well studied in several human NCDs, but these same pathways also regulate expression and function of the protein synthetic machinery and mRNA translation which have been less well investigated. Alterations in expression of specific translation factors, and disruption of canonical mRNA translational regulation, both contribute to the pathology of many NCDs. The two most common pathological alterations that contribute to NCDs discussed in this review will be the regulation of eukaryotic initiation factor 2 (eIF2) by the integrated stress response (ISR) and the mammalian target of rapamycin complex 1 (mTORC1) pathways. Both pathways integrally connect mRNA translation activity to external and internal physiological stimuli. Here, we review the role of ISR control of eIF2 activity and mTORC1 control of cap-mediated mRNA translation in some common NCDs, including Alzheimer's disease, Parkinson's disease, stroke, diabetes mellitus, liver cirrhosis, chronic obstructive pulmonary disease (COPD), and cardiac diseases. Our goal is to provide insights that further the understanding as to the important role of translational regulation in the pathogenesis of these diseases.
DOI: 10.3390/ijms21155301
PubMed: 32722591
PubMed Central: PMC7432514
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Rios-Fuller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mahe, Melanie" sort="Mahe, Melanie" uniqKey="Mahe M" first="Melanie" last="Mahe">Melanie Mahe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Walters, Beth" sort="Walters, Beth" uniqKey="Walters B" first="Beth" last="Walters">Beth Walters</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Abbadi, Dounia" sort="Abbadi, Dounia" uniqKey="Abbadi D" first="Dounia" last="Abbadi">Dounia Abbadi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Perez Baos, Sandra" sort="Perez Baos, Sandra" uniqKey="Perez Baos S" first="Sandra" last="Pérez-Baos">Sandra Pérez-Baos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gadi, Abhilash" sort="Gadi, Abhilash" uniqKey="Gadi A" first="Abhilash" last="Gadi">Abhilash Gadi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Andrews, John J" sort="Andrews, John J" uniqKey="Andrews J" first="John J" last="Andrews">John J. Andrews</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Katsara, Olga" sort="Katsara, Olga" uniqKey="Katsara O" first="Olga" last="Katsara">Olga Katsara</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Vincent, C Theresa" sort="Vincent, C Theresa" uniqKey="Vincent C" first="C Theresa" last="Vincent">C Theresa Vincent</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Schneider, Robert J" sort="Schneider, Robert J" uniqKey="Schneider R" first="Robert J" last="Schneider">Robert J. Schneider</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, NYU School of Medicine, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-communicable diseases (NCDs) are medical conditions that, by definition, are non-infectious and non-transmissible among people. Much of current NCDs are generally due to genetic, behavioral, and metabolic risk factors that often include excessive alcohol consumption, smoking, obesity, and untreated elevated blood pressure, and share many common signal transduction pathways. Alterations in cell and physiological signaling and transcriptional control pathways have been well studied in several human NCDs, but these same pathways also regulate expression and function of the protein synthetic machinery and mRNA translation which have been less well investigated. Alterations in expression of specific translation factors, and disruption of canonical mRNA translational regulation, both contribute to the pathology of many NCDs. The two most common pathological alterations that contribute to NCDs discussed in this review will be the regulation of eukaryotic initiation factor 2 (eIF2) by the integrated stress response (ISR) and the mammalian target of rapamycin complex 1 (mTORC1) pathways. Both pathways integrally connect mRNA translation activity to external and internal physiological stimuli. Here, we review the role of ISR control of eIF2 activity and mTORC1 control of cap-mediated mRNA translation in some common NCDs, including Alzheimer's disease, Parkinson's disease, stroke, diabetes mellitus, liver cirrhosis, chronic obstructive pulmonary disease (COPD), and cardiac diseases. Our goal is to provide insights that further the understanding as to the important role of translational regulation in the pathogenesis of these diseases.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32722591</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>15</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>26</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs).</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E5301</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21155301</ELocationID><Abstract><AbstractText>Non-communicable diseases (NCDs) are medical conditions that, by definition, are non-infectious and non-transmissible among people. Much of current NCDs are generally due to genetic, behavioral, and metabolic risk factors that often include excessive alcohol consumption, smoking, obesity, and untreated elevated blood pressure, and share many common signal transduction pathways. Alterations in cell and physiological signaling and transcriptional control pathways have been well studied in several human NCDs, but these same pathways also regulate expression and function of the protein synthetic machinery and mRNA translation which have been less well investigated. Alterations in expression of specific translation factors, and disruption of canonical mRNA translational regulation, both contribute to the pathology of many NCDs. The two most common pathological alterations that contribute to NCDs discussed in this review will be the regulation of eukaryotic initiation factor 2 (eIF2) by the integrated stress response (ISR) and the mammalian target of rapamycin complex 1 (mTORC1) pathways. Both pathways integrally connect mRNA translation activity to external and internal physiological stimuli. Here, we review the role of ISR control of eIF2 activity and mTORC1 control of cap-mediated mRNA translation in some common NCDs, including Alzheimer's disease, Parkinson's disease, stroke, diabetes mellitus, liver cirrhosis, chronic obstructive pulmonary disease (COPD), and cardiac diseases. Our goal is to provide insights that further the understanding as to the important role of translational regulation in the pathogenesis of these diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rios-Fuller</LastName><ForeName>Tiffany J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahe</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walters</LastName><ForeName>Beth</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbadi</LastName><ForeName>Dounia</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pérez-Baos</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-3952-0148</Identifier><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gadi</LastName><ForeName>Abhilash</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrews</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katsara</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vincent</LastName><ForeName>C Theresa</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>1RO1CA178509</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1R01CA207893</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01CA248397</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>BCRF-16-143</GrantID><Agency>Breast Cancer Research Foundation</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Int J Mol 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Rios-Fuller</name></region><name sortKey="Abbadi, Dounia" sort="Abbadi, Dounia" uniqKey="Abbadi D" first="Dounia" last="Abbadi">Dounia Abbadi</name><name sortKey="Andrews, John J" sort="Andrews, John J" uniqKey="Andrews J" first="John J" last="Andrews">John J. Andrews</name><name sortKey="Gadi, Abhilash" sort="Gadi, Abhilash" uniqKey="Gadi A" first="Abhilash" last="Gadi">Abhilash Gadi</name><name sortKey="Katsara, Olga" sort="Katsara, Olga" uniqKey="Katsara O" first="Olga" last="Katsara">Olga Katsara</name><name sortKey="Mahe, Melanie" sort="Mahe, Melanie" uniqKey="Mahe M" first="Melanie" last="Mahe">Melanie Mahe</name><name sortKey="Perez Baos, Sandra" sort="Perez Baos, Sandra" uniqKey="Perez Baos S" first="Sandra" last="Pérez-Baos">Sandra Pérez-Baos</name><name sortKey="Schneider, Robert J" sort="Schneider, Robert J" uniqKey="Schneider R" first="Robert J" last="Schneider">Robert J. Schneider</name><name sortKey="Vincent, C Theresa" sort="Vincent, C Theresa" uniqKey="Vincent C" first="C Theresa" last="Vincent">C Theresa Vincent</name><name sortKey="Walters, Beth" sort="Walters, Beth" uniqKey="Walters B" first="Beth" last="Walters">Beth Walters</name></country><country name="Suède"><region name="Svealand"><name sortKey="Vincent, C Theresa" sort="Vincent, C Theresa" uniqKey="Vincent C" first="C Theresa" last="Vincent">C Theresa Vincent</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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